PakQuizHub

1.What is the term for the dose of a medication that elicits a defined response in half of the individuals treated?

Ld50Td50Md50Ed50

2.According to the American Society of Anesthesiologists (ASA) physical status classification, what does a P2 patient represent?

A patient in perfect healthAn individual with a mild systemic illnessA person suffering from a serious systemic conditionNone of the listed categories

3.When comparing drugs A and B, which of the following statements is INCORRECT?

A dose of 1 mg of drug A produces the same effect as 3 mg of drug B, indicating that A is more potent.A 1 mg dose of drug A elicits a response that cannot be achieved even with the highest tolerated dose of drug B, showing that A has greater efficacy.A 1 mg dose of drug A causes an effect that 1 mg of drug B does not, suggesting drug A is more efficacious.The efficacy of a drug does not depend on the dose administered.None of the above.

4.How does the American Society of Anesthesiologists classify a patient under Physical Status Class III?

An individual who is completely healthyA patient experiencing mild systemic illnessA patient suffering from a severe systemic disease that is not incapacitatingNone of these choices

5.Which type of drug attaches to a receptor and triggers a response either directly or indirectly?

6.What is the term for a drug reaction that is unusual and cannot be predicted?

Unintended secondary effectHarmful toxic responseIdiosyncratic reactionInteraction between medications

7.Which of the following drugs does NOT undergo significant first-pass metabolism?

MorphineNitroglycerinPropranololSalicylates

8.The calculation of a loading dose primarily depends on which of the following parameters?

Volume of distributionDrug clearanceAdministration rateElimination half-life

9.Which of the following does NOT enhance drug metabolism by inducing cytochrome P450 enzymes?

10.Which antidote is used to treat poisoning caused by arsenic?

PenicillamineEDTADesferrioxamineBritish Anti-Lewisite (BAL)

11.In which of the following medication categories is the intramuscular route contraindicated?

Drugs used to treat high blood pressureMedications for diabetes managementBlood-thinning agentsMedications that prevent blood clot breakdown

12.What does drug efficacy specifically describe?

The spectrum of illnesses where the drug is effectiveThe highest level of response achievable by the drugThe therapeutic dosage interval of the medicationThe safety margin or therapeutic index of the drug

13.Which of the following statements about drug bioavailability is INCORRECT?

It represents the fraction of the unchanged drug that enters the systemic circulation.Bioavailability of an orally given drug can be assessed by comparing the area under the curve (AUC) after oral and intravenous administration.A low oral bioavailability always indicates poor absorption of the drug.Bioavailability can be measured using data from plasma drug levels or urinary excretion.Bioavailability reflects the rate and extent to which the active drug reaches systemic circulation.

14.What type of interaction is demonstrated by the combined use of ampicillin and gentamicin?

15.Which of the following medications undergoes a significant first-pass metabolism?

16.Which term is equivalent to neuroadaptation observed with drug use?

17.Which factor is idiosyncrasy primarily associated with?

18.Which of the following drugs exhibits zero-order kinetics in its metabolism?

19.Which statement accurately describes drugs that follow zero-order elimination kinetics?

They occur more frequently than drugs exhibiting first-order elimination.Their concentration declines exponentially over time.Their half-life remains constant regardless of the dose administered.The graph of their concentration versus time produces a straight line.

20.What is the correct formula for calculating the therapeutic index?

Lethal Dose 100 divided by Effective Dose 100Effective Dose 100 divided by Lethal Dose 100Lethal Dose 50 divided by Effective Dose 50Effective Dose 50 divided by Lethal Dose 50

Pharmacology – MCQs