Which medication is significantly metabolized during its initial passage through the liver?

Pharmaceutical Chemistry Mcqs for PPSC, FPSC, NTS, and Pakistan government job tests. Select an option below, then read the explanation.

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Published
5 Apr 2022
Last updated
28 May 2026

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Explanation

Propranolol undergoes extensive first-pass metabolism in the liver, which greatly reduces its bioavailability. In contrast, drugs like phenobarbitone, phenylbutazone, and theophylline experience less significant first-pass effects.

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